Thanks Ricardo,
This geometry was imported from a GPK file. While working with the import again the notice "Profile 'SR76_PGLLT' is too complex for civil rule creation." appeared in the message center. On a hunch the vertical curve for VPI #3 was shortened to 379.00 feet in the GPK file to remove the PVCC at station 2304+50.00.
The SR76_PGLLT profile was imported into a new file and now correctly displays the manipulator handles.
This looks like a bug to me, the original GPK file is attached if you wish to verify this.